Steatohepatitis in Morbidly Obese Patients of Roux-en-Y Gastric Bypass
Incidence and Severity of Non-alcoholic Steatohepatitis in Patients Undergoing Roux-en-Y Bypass
| Bariatric Surgery information Steatohepatitis in Morbidly Obese Patients of Roux-en-Y Gastric Bypass |
Incidence and Severity of Non-alcoholic Steatohepatitis in Patients Undergoing Roux-en-Y Bypass |
|
Weight Loss Surgery Information - Bariatric Research Studies |
Prevalence of Non-Alcoholic Steatohepatitis
in Morbidly Obese Patients Undergoing
|
Method
In 48 consecutive patients at Roux-en-Y gastric bypass, a core liver biopsy was obtained from the left lateral segment. A single liver pathologist reviewed the histology for steatosis, ballooning/disarray, necroinflammation, and fibrosis.
Results
84% of patients were female, and average BMI was 51. 18% had WHR >1. The following risk factors were present: DM 16%; hyperlipidemia 61%; HTN 47%; and abnormal LFTs 18%. 90% had abnormal liver histology, and 56% qualified for the diagnosis of non-alcoholic steatohepatitis. Only DM and abnormal LFTs were found to be significantly related to NASH.
Conclusion
Non-alcoholic steatohepatitis is a common co-morbidity of obesity and requires systemized grading and staging to develop accurate knowledge of the incidence, severity, natural history and impact of weight loss.
Source:
Spaulding L, Trainer T, Janiec D. Department of Surgery, Fletcher Allen
Health Care/University of Vermont College of Medicine, Burlington, USA.
2003