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Steatohepatitis in Morbidly Obese Patients of Roux-en-Y Gastric Bypass
Incidence and Severity of Non-alcoholic Steatohepatitis in Patients Undergoing Roux-en-Y Bypass
Prevalence of Non-Alcoholic Steatohepatitis in Morbidly Obese Patients Undergoing Roux-en-Y Gastric Bypass
Obesity is the most common cause of non-alcoholic steatohepatitis (NASH). This is a prospective study to determine the incidence and severity of non-alcoholic steatohepatitis in patients undergoing Roux-en-Y gastric bypass (RYGBP) for morbid obesity. We also examined the relationship between NASH and potential risk factors.
In 48 consecutive patients at Roux-en-Y gastric bypass, a core liver biopsy was obtained from the left lateral segment. A single liver pathologist reviewed the histology for steatosis, ballooning/disarray, necroinflammation, and fibrosis.
84% of patients were female, and average BMI was 51. 18% had WHR >1. The following risk factors were present: DM 16%; hyperlipidemia 61%; HTN 47%; and abnormal LFTs 18%. 90% had abnormal liver histology, and 56% qualified for the diagnosis of non-alcoholic steatohepatitis. Only DM and abnormal LFTs were found to be significantly related to NASH.
Non-alcoholic steatohepatitis is a common co-morbidity of obesity and requires systemized grading and staging to develop accurate knowledge of the incidence, severity, natural history and impact of weight loss.
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Laparoscopic or open bariatric surgery, such as gastric banding or bypass is not an easy solution to morbid obesity and weight loss. It is a serious surgical procedure, involving health risks. To produce lasting weight loss it requires a long-term patient commitment to eating a healthy diet and following a regular program of physical exercise. Life-long use of nutritional supplements may also be necessary. So, before deciding, discuss your options fully with your doctor. © 2003-2018 Bariatric-Surgery.Info - Terms - Contact - Information - Resources