Ghrelin Levels After Gastric Bypass Surgery
Review of Serum Ghrelin Levels in Response to Glucose Load in Obese Patients After Stomach Bypass
| Bariatric Surgery information Ghrelin Levels After Gastric Bypass Surgery |
Review of Serum Ghrelin Levels in Response to Glucose Load in Obese Patients After Stomach Bypass |
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Weight Loss Surgery Information - Bariatric Research Studies |
Serum ghrelin levels in response to glucose load in obese subjects post-gastric bypass surgeryWe sought to elucidate further the mechanisms leading to weight loss after gastric bypass (GBP) surgery in morbidly obese individuals. Ghrelin is a gastroenteric appetite-stimulating peptide hormone, fasting levels of which decrease with increasing adiposity and increase with diet-induced weight loss. In addition, ghrelin levels rapidly decline postprandially. Method We measured serum ghrelin responses to a 75-g oral glucose tolerance test (OGTT) in 6 subjects who had undergone gastric bypass surgery 1.5 +/- 0.7 years before testing and compared these responses with 6 obese subjects about to undergo gastric bypass surgery, 6 obese nonsurgical subjects (matched for BMI to the post-GBP surgical group), and 5 lean subjects. Results Despite weight loss induced by the gastric bypass surgery, fasting serum ghrelin levels were significantly lower in the post-gastric bypass surgery group than in the lean subject (by 57%) or pre-gastric bypass surgery (by 45%) group. Serum ghrelin levels during the OGTT were significantly lower in postoperative than in lean, obese pre-gastric bypass surgical, or obese nonsurgical subjects. The magnitude of the decline in serum ghrelin levels between 0 and 120 minutes post-OGTT was significantly smaller in postoperative (by 62%), obese pre-gastric bypass surgical (by 80%), or obese nonsurgical (by 69%) subjects in comparison with lean subjects. Discussion Serum ghrelin levels in response to OGTT are lower in subjects post-gastric bypass surgery than in either lean or obese subjects. Tonically low serum ghrelin levels may be involved in the mechanisms inducing sustained weight loss after gastric bypass surgery. Source: Bariatric Weight Loss Surgery |