Effect of Surgical Weight Loss on Free Radical and Antioxidant Balance
Free Radical Levels Fall After Weight Loss From Stomach Gastroplasty
| Bariatric Surgery information Effect of Surgical Weight Loss on Free Radical and Antioxidant Balance |
Free Radical Levels Fall After Weight Loss From Stomach Gastroplasty |
|
Weight Loss Surgery Information - Bariatric Research Studies |
Effect of Surgical Weight Loss on Free Radical and Antioxidant Balance: A Preliminary ReportThis study observes the effect of surgical weight loss on free radical and antioxidant vitamin balance. Method 22 consecutive morbidly obese patients undergoing vertical banded gastroplasty (VBG) were chosen for the study. Postoperative studies were done at 12 and 24 weeks. Plasma antioxidant and vitamin determinations were performed by HPLC method. Results Subjects lost a significant amount of weight. Compared to preoperative measurements, postoperative measurements of plasma beta-carotene were not statististically different both at 12 and 24 weeks. Alpha-tocopherol increased slightly at the 12th week; the difference was not significant. The levels of alpha-tocopherol rose at 24th week significantly. The indicator of lipid peroxidation (malondialdehyde) decreased with weight loss. Conclusion Our data show that free radical generation falls markedly in association with weight loss after vertical banded gastroplasty. Surgical weight loss leads to significant decrease in oxidant production and also leads to increase in some antioxidant vitamins. The demonstration of decreased free radical generation and correction of balance between free radicals and antioxidant vitamins has important implications for oxidative mechanisms underlying obesity-associated disorders Source: Gastric Bypass Weight Loss Surgery |