Effect of Gastric Surgery Weight Loss on Insulin Inhibition
Surgical Weight Loss Improves Insulin-induced Glucose Uptake, Normalizes Insulin Inhibition
| Bariatric Surgery information Effect of Gastric Surgery Weight Loss on Insulin Inhibition |
Surgical Weight Loss Improves Insulin-induced Glucose Uptake, Normalizes Insulin Inhibition |
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Weight Loss Surgery Information - Bariatric Research Studies |
Restored insulin inhibition on insulin secretion
in nondiabetic severely obese patients after
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Method
Longitudinal, clinical intervention study--bariatric surgery (vertical banded gastroplasty--gastric bypass--Capella technique), re-evaluation after 4 and 14 months.
Subjects
Nine obese patients class III (BMI=54.6+/-2.6 kg/m2) and nine lean subjects (BMI=22.7+/-0.7 kg/m2).
Measurements
Euglycemic hyperinsulinemic clamp (insulin infusion: 40 mU/min m2), C-peptide plasma levels, electrical bioimpedance methodology, and oral glucose tolerance test (OGTT).
Results
BMI was reduced in the follow-up: 44.5+/-2.2 and 33.9+/-1.5 kg/m2 at 4 and 14 months. Insulin-induced glucose uptake was markedly reduced in obese patients (19.5+/-1.9 micromol/min kg FFM) and improved with weight loss, but in the third study, it was still lower than that observed in controls (35.9+/-4.0 vs 52.9+/-2.2 micromol/min kg FFM). Insulin-induced inhibition of its own secretion was blunted in obese patients (19.9+/-5.7%, relative to fasting values), and completely reversed to values similar to that of lean ones in the second and third studies (-60.8+/-4.2 and -54.0+/-6.1%, respectively).
Conclusion
Weight loss in severe obesity improved insulin-induced glucose uptake, and completely normalized the insulin inhibition on its own secretion.
Source:
Pereira JA, Claro BM, Pareja JC, Chaim EA, Astiarraga BD, Saad MJ, Muscelli
E. Departmento de Clinica Medica, Faculdade de Ciencias Medicas, Universidade
Estudual de Campinas (UNICAMP), Sao Paulo, Brazil.
National Library of Medicine 2003