Effect of Roux-en-Y Gastric Bypass Surgery on Bone Mass, Metabolism
Postmenopausal Women, Roux-en-Y Stomach Bypass, Secondary Hyperparathyroidism
| Bariatric Surgery information Effect of Roux-en-Y Gastric Bypass Surgery on Bone Mass, Metabolism |
Postmenopausal Women, Roux-en-Y Stomach Bypass, Secondary Hyperparathyroidism |
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Weight Loss Surgery Information - Bariatric Research Studies |
Effect of Roux-en-Y Gastric Bypass Surgery
on Bone Mass, Metabolism:
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Method
Bone mineral density and bone mineral content (BMC) were examined in 44 RYGB women (> or = 3 years post-surgery; 31% weight loss; BMI, 34 kg/m(2)) and compared with age- and weight-matched control (CNT) women. In a separate analysis, Roux-en-Y gastric bypass women who presented with low bone mass were supplemented to a total 1.2 g Ca/d and 8 microg vitamin D/d over 6 months and compared with an unsupplemented CNT group (n = 13). Bone mass and turnover and serum parathyroid hormone (PTH) and 25-hydroxyvitamin D were measured.
Results
Bone mass did not differ between premenopausal RYGB and CNT women (42 +/- 5 years), whereas postmenopausal RYGB women (55 +/- 7 years) had higher bone mineral density and BMC at the lumbar spine and lower BMC at the femoral neck. Before and after dietary supplementation, bone mass was similar, and serum PTH and markers of bone resorption were higher in Roux-en-Y gastric bypass compared with CNT women and did not change significantly after supplementation.
Discussion
Postmenopausal Roux-en-Y gastric bypass women show evidence of secondary hyperparathyroidism, elevated bone resorption, and patterns of bone loss (reduced femoral neck and higher lumbar spine) similar to other subjects with hyperparathyroidism. Although a modest increase in Ca or vitamin D does not suppress PTH or bone resorption, it is possible that greater dietary supplementation may be beneficial.
Source:
Goode LR, Brolin RE, Chowdhury HA, Shapses SA. Department of Nutritional
Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA.
National Library of Medicine 2004