Effect of Gastric Banding on Aminoterminal Pro-Brain Natriuretic Peptide
About Stomach Banding Effect
| Bariatric Surgery information Effect of Gastric Banding on Aminoterminal Pro-Brain Natriuretic Peptide |
About Stomach Banding Effect |
| Effect of Gastric Banding on Aminoterminal Pro-Brain Natriuretic Peptide in the Morbidly Obese Aminoterminal pro-brain natriuretic peptide (NT-proBNP), like brain natriuretic peptide, might have diagnostic utility in detecting left ventricular hypertrophy and/or left ventricular dysfunction. The aim of the study was to investigate the relationship between morbid obesity and NT-proBNP and the effect of weight reduction on this parameter. Method A total of 34 morbidly obese patients underwent laparoscopic adjustable gastric banding (LAGB). NT-proBNP levels were measured before and 12 months after the surgery. Results Metabolic features and systolic and diastolic blood pressure were significantly decreased after a cumulative weight loss of 19.55 kg 1 year after LAGB. NT-proBNP concentration was significantly higher in morbidly obese patients before LAGB than in normal-weight control subjects. After bariatric surgery, NT-proBNP concentration decreased significantly from 341.15 +/- 127.78 fmol/mL to 204.87 +/- 59.84 fmol/mL and remained statistically significantly elevated compared with normal-weight subjects. Discussion This investigation demonstrates higher levels of NT-proBNP in morbidly obese subjects and a significant decrease during weight loss after laparoscopic adjustable gastric banding. In obesity, NT-proBNP might be useful as a routine screening method for identifying left ventricular hypertrophy and/or left ventricular dysfunction. Source: Surgery to Reduce Obesity |