Effects of Adjustable Gastric Banding on Immunological Markers
About AGB and Immune System
| Bariatric Surgery information Effects of Adjustable Gastric Banding on Immunological Markers |
About AGB and Immune System |
| Acute-Phase Response And Immunological Markers In Morbid Obese Patients And Patients Following Adjustable Gastric Banding We measured markers of acute-phase response and immunological markers in morbid obese patients and in formerly morbid obese patients after a massive weight loss following adjustable gastric banding (AGB). Method A total of 49 morbid obese female patients with a body mass index (BMI) above 40 kg/m(2) were investigated during a study period of 6 months. Of these, 24 patients received adjustable gastric banding and lost a minimum of 20 kg in 1 y (AGB group) and 25 patients maintained their weight (obese group). In sum, 13 normal weight subjects (BMI<24 kg/m(2)) were taken for controls. Plasma concentration of the acute-phase proteins, C-reactive protein (CRP), orosomucoid, complement factors C3 and C4 and white blood cell count, lymphocyte subsets and serum immunoglobulins were analyzed. Results Acute-phase proteins were significantly lower in the adjustable gastric banding group compared to morbid obese patients and remained significantly elevated in the adjustable gastric banding group compared to controls. In addition, leukocytes, polymorphonuclear leukocytes and lymphocytes were significantly lower after adjustable gastric banding and reached levels comparable to controls (except PMN). No difference in CD3 counts was observed in the three groups. CD4 increased and CD8 decreased in obese and adjustable gastric banding patients when compared to controls whereas no statistical difference was found between obese and adjustable gastric banding patients. Conclusion Our results confirm the positive effect of adjustable gastric banding followed by a massive weight loss without apparent malnutrition. Subclinical chronical inflammation in morbid obese patients leads to irregularities in leukocyte and lymphocyte subsets. These alterations can be positively influenced by adjustable gastric banding. Source: Surgery to Reduce Obesity |