Effect of Obesity Surgery on Macrophage Inhibitory Factor Levels
About Inflammatory Mediators After Gastric Restrictive Surgery
| Bariatric Surgery information Effect of Obesity Surgery on Macrophage Inhibitory Factor Levels |
About Inflammatory Mediators After Gastric Restrictive Surgery |
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Weight Loss Surgery For Class 3 Obesity - Research Into Gastric Reduction Surgery |
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Effect of Obesity Surgery on Macrophage Inhibitory Factor Levels Obesity is demonstrated to be associated with an enhanced inflammatory state, which is suggested to be a cause for the development of obesity-related morbidity. It was hypothesized that a decrease in body weight in morbid obese subjects would lead to a reduction of the inflammatory state in these subjects. Study Method Weight loss was achieved by gastric restrictive surgery in 27 morbidly obese patients. Preoperative as well as 3-, 6-, 12-, and 24-month postoperative plasma concentrations of inflammatory mediators macrophage inhibitory factor, plasminogen activator inhibitor-1, lipopolysaccharide binding protein, -1 acid glycoprotein, C-reactive protein, soluble TNF receptors 55 and 75, and leptin were measured. Study Results Macrophage inhibitory factor levels remained low normal for 6 months, during weight loss, after which they significantly increased to normal levels at 24 months postoperatively. The other inflammatory mediators remained elevated up to minimally 3 months postoperatively; thereafter they decreased significantly. Both TNF receptors remained elevated up to at least 12 months postoperatively to decrease significantly at 2 year postoperatively. Conclusion This study demonstrates that during weight loss, after gastric restrictive surgery, inflammatory mediators remain elevated for at least 3 months postoperatively, suggesting initially an ongoing inflammatory state. However, 2 year after surgery, the inflammatory mediators reach near normal values. Authors: Source: Stomach Bypass Surgery Information |