Hyperhomocysteinemia After Gastroplasty for Severe Obesity
Vitamin Deficiencies After
Surgical Gastroplasty
| Bariatric Surgery information Hyperhomocysteinemia After Gastroplasty for Severe Obesity |
Vitamin Deficiencies After |
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Weight Loss Surgery For Class 3 Obesity - Research Into Gastric Reduction Surgery |
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Instances of Hyperhomocysteinemia After Gastroplasty for Severe Obesity Severe obesity exposes patients to an increased risk of cardiovascular mortality. Gastroplasty has been shown to induce substantial weight loss and to improve the atherogenic profile of severely obese subjects. However, vitamin deficiencies after gastroplasty have been reported. Because hyperhomocysteinemia, an independent risk factor for cardiovascular disease, is influenced by nutritional status (and especially by folate intake), we hypothesized that a marginal folate deficiency induced by gastroplasty could promote hyperhomocysteinemia. Method Thus, plasma homocysteine concentrations were measured by high-performance liquid chromatography in 53 severely obese patients, before and 1 year after vertical gastroplasty. Results Plasma homocysteine concentrations increased, on an average, from 9.9 ± 0.4 to 12.8 ± 0.6 µmol/L. This increase in homocysteine levels was observed in two thirds of the subjects, leading to clear-cut hyperhomocysteinemia in 32%. The changes in homocysteine concentrations were correlated to weight loss and to decrease in plasma folate concentrations. Whereas gastroplasty induced a mean 32-kg weight loss and a striking improvement in conventional risk factors, the occurrence of iatrogenic hyperhomocysteinemia might hamper the benefit of surgery on cardiovascular risk in most of the patients. Conclusion Our results further support use of a systematic efficient folate supplementation after gastroplasty. Authors: Source: Stomach Bypass Surgery Information |