Gastric Bypass Surgery Leads to a Decrease in Bone Mass
Impact of Laparoscope-Assisted Roux-en-Y Bypass on Bone Turnover
| Bariatric Surgery information Gastric Bypass Surgery Leads to a Decrease in Bone Mass |
Impact of Laparoscope-Assisted Roux-en-Y Bypass on Bone Turnover |
Guide to Weight Loss Surgery - Research Into Gastric Reduction Surgery |
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Gastric Bypass Surgery Leads to a Decrease in Bone Mass Little is known about the effects on the skeleton of laparoscopic Roux-en-Y gastric bypass (LRGB) surgery for morbid obesity and subsequent weight loss. Method We compared 25 patients who had undergone laparoscopic Roux-en-Y gastric bypass 11 ± 3 months previously with 30 obese controls matched for age, gender, and menopausal status. Results Compared with obese controls, patients post LRGB had significantly lower weight and body mass index. Markers of bone turnover were significantly elevated in patients post laparoscopic Roux-en-Y gastric bypass compared with controls. Fifteen patients were studied prospectively for an average of 9 months after LRGB. They lost 37 ± 9 kg and had a 29 ± 8% fall in body mass index. Urinary N-telopeptide cross-linked collagen type 1 increased by 174 ± 168% at 3 months and 319 ± 187% at 9 months. Bone mineral density decreased significantly at the total hip, trochanter, and total body, with significant decreases in bone mineral content at these sites. Summary Within 3-9 months after laparoscopic Roux-en-Y gastric bypass, morbidly obese patients have an increase in bone resorption associated with a decrease in bone mass. Additional studies are needed to examine these findings over the longer term. Sources: Gastric Bypass Surgery Information |